Uses of Sildenafil

Sildenafil is used to treat pulmonary arterial hypertension and to improve penile functions.

Therapeutic Category

Sildenafil: Phosphodiesterase type 5 (PDE 5) inhibitors

How Sildenafil works

Sildenafil works by blocking the effects of certain enzymes (PDE5) within the body which limits blood flow to the lungs and penis. As a result, it causes widening of blood vessels (arteries) supplying these organs, increases blood flow and oxygen supply and improves their functions.

Common side effects of Sildenafil

• headache
• flushing
• indigestion, diarrhoea
• pain in the arms or legs
• vision problems
• flu-like symptoms, inflammation of the sinuses, fluid retention
• difficulty in sleeping, anxiety, shaking
• sensation of pins and needles
• vertigo (spinning sensation)
• nosebleed, runny nose, cough, stuffy nose
• nausea, vomiting, stomach inflammation, heartburn, piles, abdominal distension, dry mouth, diarrhea
• hair loss
• skin redness, night sweats
• muscle pain, back pain
• increased erections

When to consult your doctor

Consult your doctor if you experience:

• prolonged or painful erection (priapism)
• sudden decline or loss of vision
• fits or seizures
• pneumonia, abnormal heartbeat, chest pain, fainting
• infections (viral infection of the gut, urinary tract infections and tooth cavities)
• fits, hearing impairment inflammation of digestive tract

Health Tips for Sildenafil

• Sildenafil is not suitable for use in women
• Sildenafil is generally more effective when taken on an empty stomach
• Avoid consumption of alcohol or grapefruit juice while taking Sildenafil as it may increase its side effects
• Avoid using recreational drugs (like amyl nitrate, etc.) while taking sildenafil as it may cause a dangerous drop in blood pressure
• Sildenafil should not be taken more than once in a 24-hour period
• Before taking Sildenafil, inform your doctor if you have any liver, kidney, or heart problems

Inform your doctor if you are pregnant, breastfeeding or planning to have an baby, or are breastfeedingMore information about using Sildenafil is available in the medication information available at. More information about using Sildenafil is available in the medication information available at.

Op±+ Sildenafil

Sildenafil is a medical professional (such as your doctor) will provide you with specific instructions for using this medicine. It is important that you follow the instructions provided by your doctor or pharmacist. If you have any concerns about using this medicine, you should consult your doctor or pharmacist first.

Op±+ Sildenafil (Sildenafil 100mg +ikini)

This medicine contains Spedra 100mg +VERTISRA

Uses of Op±+ Sildenafil

Op±+ Sildenafil is used to treat pulmonary arterial hypertension and to improve penile functions.

Does Op±+ Sildenafil work?

Op±+ Sildenafil is effective only when taken with an empty stomach. It may be taken with or without food. You should consult your doctor if you would like to use this medicine.

How to take Op±+ Sildenafil?

• Take the tablets as advised by your doctor. If you forget to take a dose, take it as soon as you remember. Do not take a double dose to make up for the missed dose.

Viagra 50mg tablet contains an active component such as Sildenafil. This medication is used to treat erectile dysfunction (ED) in men. It contains the active ingredient sildenafil citrate, which belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. It increases blood flow to the penis during sexual stimulation, which helps men achieve and maintain an erection. Viagra may have side effects, including headache, flushing, dizziness, upset stomach, nasal congestion, and vision changes. It should not be taken with certain medications or conditions, so it's crucial to consult a healthcare professional before using it. Erectile dysfunction can have a profound impact on a man's self-esteem and quality of life. By addressing ED, this medication can help improve a person's sense of well-being and overall happiness.

Individuals with a history of cardiovascular diseases, such as heart problems (angina, heart failure, irregular heartbeats) or recent heart attack, should exercise caution when using Viagra. The sexual activity itself can strain the heart and can further increase the strain by increasing blood flow. Consult with a healthcare professional to assess the risks and benefits in such cases. This medication can cause a mild decrease in blood pressure. Caution is advised for individuals with low blood pressure or those taking medications that lower blood pressure, as combining these can lead to potentially harmful interactions. People with severe liver or kidney disease may experience slower elimination of Viagra from the body, leading to a prolonged effect. Dosage adjustments may be necessary in such cases.

What is Erectile dysfunction?

Men with Erectile dysfunction (ED) may be advised to consult with a healthcare provider to assess for possible risks and benefits. However, this may require immediate medical attention. Patients should not take this medication if they have any of the following health conditions:

• Severe hypotension
• Dizziness
• Tachycardia
• Tension
• Tremors

Some individuals may experience side effects with this medication. The most common side effects include headache, anemia, decreased libido, and sleep problems. Some people may also experience flushing or indigestion, which is defined as chest pain or flushing in association with activities such as walking or standing. Manage | |Erectile dysfunction

Who should not use this tablet?

No specific side effects or side effects that should not be used with Viagra 50mg tablet are more than ever.

Do not use Viagra 50mg tablet if you are allergic to sildenafil or any of its ingredients. Do not consume alcohol with Viagra if you are taking any of the following medications:

• Antihyperimycotic medications like Amantadine or Lopressor
• Sildenafil citrate medications such as Avanafil or Sildenafil
• Other medications like Nitro-Duril (a nitrate drug)
• Methazol, Isosorbide, Isosorbide Mononitrate, or Monnitrosyml
• Tadalafil

Men should consult a healthcare professional for safe and appropriate treatment.

Common side effects

The side effects include headache, anemia, decreased libido, and sleep problems. Report to your healthcare provider if any of these side effects worsen.

Common side effects may include upper left calf pain, calf pain, pain or swelling in the calf, nausea, calf pain, calf swelling, pain, pain, and swelling in the leg, ankles, or feet, and weakness in the lower legs. Manage to understand the potential side effects associated with Viagra 50mg tablet and seek immediate medical attention.

Is Viagra a muscle relaxant?

Viagra can improve blood flow in certain muscles, thereby helping men achieve and maintain an erection. However, it can cause side effects, including muscle pain, dizziness, and nausea. Consult with a healthcare professional to assess the potential side effects in these specific situations.

Some individuals may experience side effects with is a muscle relaxant. This medication is thought to relax the muscles in certain parts of the blood vessels, thereby increasing blood flow to specific areas of the body. Manage to understand the potential side effects associated with Viagra tablet and seek medical attention if you experience any of the following symptoms.

I have severe muscle pain. I have severe cold sores.

Product Name:Viagra

Ingredients:Sildinafil 50mg

Product Type:Tablet

Product size:6's

Company:Pfizer

Used for:

• Viagra Tabs is approves for the treatment of men who have difficulty having and maintaining an erection, Otherwise know as impotence.
• Viagra Tab work faster only 20 minutes as compared to traditional Viagra pills that takes 60 to +0 minutes become effective.

How to take tablets

Swallow tablets whole with a drink of water or juice (but not grapefruit juice).

For erectile dysfunction, it's best to take sildenafil on an empty stomach. It may take longer to work if you take it with food.

How to take liquid

If you or your child are taking sildenafil as a liquid, 1ml is usually the same as taking a 10mg tablet, but it's important to always check the medicine label.

Liquid sildenafil will usually be made up for you by your pharmacist.

The medicine will come with a plastic syringe or spoon to help you take the right amount. If you do not have a plastic syringe or spoon, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not measure the right amount.

If you take too much

Taking too much sildenafil can cause unpleasant side effects.

Talk to your doctor if you take too much sildenafil and you're worried about any of these side effects:

• headaches
• dizziness
• indigestion
• blocked nose
• changes to your vision

You should always tell your doctor if you have any of these conditions:

• poop or bleeding disorders
• prostate problems
• eye or eye problems such as retinitis pigmentosa
• a stomach bleeding medication
• diabetes
• glaucoma
• glaucoma-induced angina
• hypertension
• heart disease
• joint disorder
• heart irregularity or heart attack
• Moderate or severe kidney disease
• prescription drug condition
• severe liver disease

Taking other medicines

Tell your doctor if your prescription isn't longer.

Other medicines such as sildenafil (Viagra) and sildenafil-citrate may interact with sildenafil. It's important to let your doctor know if you are taking any other medicines.

If you have any other erectile dysfunction

Your doctor may have prescribed sildenafil for conditions other than just erectile dysfunction. See also Precautions section.

Not suitable for men under the age of 18 years

Sildenafil isn't suitable for men under the age of 18 years for the following reasons:

• Cause low blood pressure
• Do not use certain medications (such as nitrates)
• Have no effect if you're in penile tissue
• Have no effect if you're sexually stimulated
• Have no effect on your ability to achieve or maintain an erection
• Have a history of priapism
• Have a history of any other serious side effects from taking sildenafil

Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines and sildenafil may interfere with each other.

Abstract

Thein vitrorelease of sildenafil citrate (Viagra, Pfizer Inc., USA) is a useful and cost-effective treatment for erectile dysfunction (ED) in men. However, a number of factors may influence the in vivo efficacy of sildenafil citrate. In this study, the objective of this study was to compare the effects of sildenafil citrate (Viagra, Pfizer Inc., USA) in patients with ED treated with a clinically appropriate dose of sildenafil citrate (Viagra, Pfizer Inc., USA).

Materials and Methods

In this study, the efficacy of sildenafil citrate (Viagra, Pfizer Inc., USA) and sildenafil citrate (Viagra, Pfizer Inc., USA) were evaluated in 20 patients with ED treated with a clinically appropriate dose of sildenafil citrate (Viagra, Pfizer Inc., USA) for up to 14 days. The efficacy of sildenafil citrate (Viagra, Pfizer Inc., USA) and sildenafil citrate (Viagra, Pfizer Inc., USA) was compared with sildenafil citrate (Viagra, Pfizer Inc., USA) at the same dose. In addition, sildenafil citrate (Viagra, Pfizer Inc., USA) was evaluated in healthy male volunteers.

Results

The mean maximum serum concentrations of sildenafil citrate (Viagra, Pfizer Inc., USA) and sildenafil citrate (Viagra, Pfizer Inc., USA) in 20 patients with ED treated with sildenafil citrate (Viagra, Pfizer Inc., USA) were 3.12 and 2.98 µg/dL, respectively. The mean serum concentrations of sildenafil citrate (Viagra, Pfizer Inc., USA) were 8.20 and 7.33 µg/dL in the 20 patients with ED treated with sildenafil citrate (Viagra, Pfizer Inc., USA) and sildenafil citrate (Viagra, Pfizer Inc., USA), respectively. The mean serum concentrations of sildenafil citrate (Viagra, Pfizer Inc., USA) were 8.20 and 5.20 µg/dL in the 20 patients with ED treated with sildenafil citrate (Viagra, Pfizer Inc., USA) and sildenafil citrate (Viagra, Pfizer Inc., USA), respectively.

Conclusion

Viagra (Viagra, Pfizer Inc., USA) is a cost-effective treatment for ED in patients with ED who do not respond to the standard dose of sildenafil citrate (Viagra, Pfizer Inc., USA). The sildenafil citrate (Viagra, Pfizer Inc., USA) dose is a clinically appropriate dose for the treatment of ED in men with ED.

Citation:Takeda R, Wang Y-H, Wang L-Y, Chen B-Z, Zhang S-G, et al. (2022) Comparison of In Vitro and In vivo Efficacy of Viagra (Viagra, Pfizer Inc., USA) in Adults with Erectile Dysfunction Treated with a Prescribed Treatment for ED. PLoS ONE 17(9): e0229633. https://doi.org/10.1371/journal.pone.0229633

Editor:F. C. L. S. Poon, F. H. T. W. Kim, National University of Singapore, Singapore

Received:February 28, 2022;Accepted:December 4, 2022;Published:January 18, 2025

Copyright:© 2025 Takeda et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Data Availability:All relevant data are within the paper and its files.

Funding:This study was supported by the National Natural Science Foundation of China (grant no. 51673002), the National Natural Science Foundation of China (grant no. 81401010), and the National Basic Research Program of China (no. 2012CB932402).